Stiripentol can be a CYP3A4 inhibitor and inducer. Monitor CYP3A4 substrates coadministered with stiripentol for amplified or decreased consequences. CYP3A4 substrates could have to have dosage adjustment.
Monitor Intently (1)modafinil will enhance the stage or effect of flibanserin by impacting hepatic enzyme CYP2C19 metabolism.
modafinil will reduce the level or impact of fruquintinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. If coadministration with average CYP3A4 inducers is unavoidable, continue to administer fruquintinib at advised dosage.
Existing trials of modafinil for fatigue and EDS related to PD, MS, TBI and PPS offered inconsistent outcomes. Nearly all of the experiments had small sample measurements. Modafinil is not nevertheless sufficient to get recommended for these healthcare problems right up until strong info are offered.
Monitor Intently (one)mitotane decreases amounts of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. Mitotane is a strong inducer of cytochrome P-4503A4; watch when coadministered with CYP3A4 substrates for probable dosage changes.
Keep track of Carefully (one)crofelemer improves amounts of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. Crofelemer has the potential to inhibit CYP3A4 at concentrations predicted during the intestine; not likely to inhibit systemically due to the fact minimally absorbed.
Tic disorders, like Tourette’s syndrome, which can be worsened by stimulants like modafinil.
Caffeine, a methylxantine derivative, continues to be made use of to be a psychoactive drug for a lengthy length of time. For healthful Grown ups, the halflife of caffeine is 5 several hours and it can be prolonged nearly 11 several hours for Expecting Gals or women using beginning control capsules [26]. Caffeine acts as an antagonist of adenosin receptors [27,28]. Pharmaceutically, caffeine is often a stimulant of metabolism and the central anxious method but can also be utilized for a Life style drug plus a clinical drug to lessen physical get more info fatigue and manage alertness.
mitotane decreases levels of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Mitotane is a solid inducer of cytochrome P-4503A4; keep track of when coadministered with CYP3A4 substrates for feasible dosage adjustments.
carbamazepine will lower the level or impact of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
Modafinil is used to take care of a lot of sleepiness that may come about with snooze apnea, narcolepsy, or change function challenges.
It's not necessarily regarded irrespective of whether this medicine will harm an unborn little one. Notify your physician For anyone who is Expecting or approach to be Expecting.
enzalutamide will lower the level or effect of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
Check Intently (one)levoketoconazole will boost the amount or result of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism.